1. Nisin
Nisin, CAS 1414-45-5, E234, molecular formula C143H230N42O37S7, molecular weight 3354.0705.
It is a polypeptide produced by Streptococcus lactis, consisting of 34 amino acid residues, which is quickly hydrolyzed into amino acids under the action of human physiological pH conditions and α-tryptic rennet, and will not change the normal flora in the human intestinal tract and produce resistance problems such as other antimicrobials, not to mention cross-resistance with other antimicrobials, and is a highly effective, non-toxic, safe and non-side effect natural food. It is a natural food preservative with high efficiency, non-toxic, safe, and has no side effects.
Since nisin can inhibit most gram-positive bacteria and has a strong inhibitory effect on the spores of Bacillus, it is widely used as a food preservative in the food industry.
2. Mechanism of action of nisin
Nisin is a hydrophobic, positively charged small peptide, which can adsorb on the cell membrane of Gram-positive sensitive bacteria and interact with negatively charged substances in the cell wall (such as phosphopeptide, glyoxylate, acidic polysaccharide, or phospholipid), and can invade into the cell membrane through the C-terminus to form a permeable pore, inhibit the synthesis of the cell wall of Gram-positive bacteria, change the permeability of the cell membrane, and cause the small molecules in the cell At the same time, the influx of extracellular water molecules causes the cell to die by autolysis.
3. Application scope of nisin
It can be widely used in meat products, dairy products, canned food, seafood, beverages, juice drinks, liquid eggs, and egg products, spices, brewing process, baked food, convenience food, fragrance-based spices, cosmetic field, etc.
4. Nisin Manufacturers
The manufacturers of nisin include Shandong Freda Biotechnology Co., Ltd, Weiri (Shandong) Biotech Co., Ltd, Zhejiang Silver Elephant Bioengineering Co., Ltd, Yota Bio-Engineering Co., Ltd, Hebei Shengxue Dacheng Pharmaceutical Co., Ltd, Amtech Biotech Co., Ltd, Siveele, Handary.
4.1 Shandong Freda Biotechnology Co., Ltd
Shandong Freda Biotechnology Co., Ltd was established in 2008, the company takes biological fermentation raw materials as the direction of industrialization, mainly devoted to the research and development, production, and sales of biological preservatives and cosmetic raw materials. For food additives, the main products are natamycin, nisin and compound food preservatives, etc. For cosmetic efficacy raw materials, the main products are ectoin, boswellin, polyglutamic acid sodium, polyglutamic acid hydrogel, and pullulan polysaccharide.
4.2 Weiri (Shandong) Biotech Co., Ltd
Weiri (Shandong) Biotech Co., Ltd is located in Yucheng City, Shandong Province. It is an innovative and modernized enterprise integrating R&D, production, and sales of bioengineering products. The company was prepared in 2014 and can produce 2,000 tons of nisin and 18,000 tons of sodium lactate annually.
4.3 Zhejiang Silver Elephant Bioengineering Co., Ltd
Zhejiang Silver Elephant Bioengineering Co., Ltd is located in Taizhou City, Zhejiang Province, which is a national high-tech enterprise that specializes in the production of biological food preservatives using modern biotechnology.
The company is one of the early enterprises engaged in the production of biological preservatives in China and is also one of the few enterprises in China that can simultaneously have the industrialized production capacity of three series of products: nisin, natamycin, ε-polylysine and its hydrochloride.
4.4 Yota Bio-Engineering Co., Ltd
Founded in June 2014, Yota Bio-Engineering Co., Ltd is a joint-stock high-tech bioengineering company with a legal address in Rizhao City, Shandong Province.
The company is dedicated to the research, development, production, and operation of biological food additive products, currently, the main products are nisin, natamycin, and TG enzyme (glutamine aminotransferase).
4.5 Hebei Shengxue Dacheng Pharmaceutical Co., Ltd
Founded in 1997, Hebei Shengxue Dacheng Pharmaceutical Co., Ltd. is a modern pharmaceutical enterprise headquartered in Shijiazhuang City, Hebei Province.
It has four production bases. The company’s leading products include oxytetracycline base, oxytetracycline hydrochloride, streptomycin sulfate, colistin sulfate, neomycin sulfate, nisin, etc.
4.6 Amtech Biotech Co., Ltd
Amtech Biotech Co., Ltd. is located in Qiqihar City, Heilongjiang Province, established in 2006. It is a globally important professional manufacturer of natural food bio-preservatives, with bio-engineering technology as the core driving force and fermented natural food bio-preservatives and yeast as the leading products, aiming to provide natural food bio-preservative solutions and full industrial chain coverage.
4.7 Siveele
With 20 years of experience in the biotechnology industry, Siveele is regarded as one of the leaders in the development of natural protective ingredients and solutions, providing protection solutions for feed, food, personal&health care, and the pharmaceutical industry.
Based on our experience with Nisin, Natamycin and ε-Polylysine, Siveele keeps on creating innovative and healthy solutions with more natural ingredients.
4.8 Handary
Handary is a global supplier of natural shelf life solutions serving the food and beverage industries. We deliver combined experimental food-deterioration diagnostics and natural shelf-life ingredients to effectively stabilize food quality attributes during the shelf life.
5. Summary
Nisin is a natural preservative derived from the fermentation of Streptococcus lactis, which is safe and efficient.
The nisin producers are Shandong Freda Biotechnology Co., Ltd, Weiri (Shandong) Biotech Co., Ltd, Zhejiang Silver Elephant Bioengineering Co., Ltd, Yota Bio-Engineering Co., Ltd, Hebei Shengxue Dacheng Pharmaceutical Co., Ltd, Amtech Biotech Co., Ltd, Siveele, Handary.
