1. Vitamin b6
Vitamin B6, also known as pyridoxine, pyridoxine hydrochloride, CAS 65-23-6, chemical formula C8H10NO5P molecular weight 205.64.
It exists in the form of phosphate ester in the body and is a water-soluble vitamin that is easily destroyed by light or alkali and is not resistant to high temperatures. Vitamin B6 is a colorless crystal, easily soluble in water and ethanol, stable in acid, and easily destroyed in alkali, pyridoxine is heat resistant, but pyridoxal and pyridoxamine are not heat resistant. Vitamin B6 is more abundant in yeast, liver, cereals, meat, fish, eggs, beans, and peanuts.
Vitamin B6 downstream is mainly used in medicine, food and health care, feed, and other fields, of which the feed field accounts for the largest proportion. The products are divided into pharmaceutical grade, food grade, and feed grade.
2. Physiological functions of vitamin b6
Vitamin b6 is involved in nearly 100 enzymatic reactions mainly in the form of pyridoxal phosphate (PLP). Most are related to amino acid metabolism: including transamination, decarboxylation, side-chain cleavage, dehydration, and transsulfuration. These biochemical functions are involved in various aspects.
1. Involved in protein synthesis and catabolism, involved in all amino acid metabolism, such as related the metabolism of heme and related to the synthesis of niacin from tryptophan.
2. Involved in gluconeogenesis, and UFA metabolism. It is related to the metabolism of glycogen, neurosphingolipids, and steroids.
3. Involved in the synthesis of certain neuromediators (5-hydroxytryptamine, taurine, dopamine, norepinephrine, and γ-aminobutyric acid).
4. Vitamin B6 and a carbon unit, vitamin B12, and folic acid salt metabolism, if they metabolic disorders can cause megaloblastic anemia.
5. Involved in nucleic acid and DNA synthesis, deficiency can impair DNA synthesis, this process is very important to maintain appropriate immune function.
6. Vitamin B6 is very closely related to vitamin B2, and vitamin B6 deficiency is often accompanied by vitamin B2 symptoms.
7. Involved in the conversion of homocysteine to methionine, has a role in reducing chronic disease, mild hyperhomocysteinemia is considered a possible risk factor for vascular disease, and vitamin B6 intervention can reduce plasma homocysteine levels.
3. Main manufacturers of vitamin b6
The main manufacturers of vitamin b6(pyridoxine hydrochloride) are Jiangxi Tianxin Pharmaceutical Co., Ltd, DSM, Xinfa Pharmaceutical Co., Ltd, Huazhong Pharmaceutical Co., Ltd, Hubei Guangji Pharmaceutical Co., Ltd (Hubei Huisheng Pharmaceutical Co., Ltd), Shanghai Hegno Pharmaceutical Holding Co., Ltd and Zhejiang NHU Co., Ltd.
3.1 Jiangxi Tianxin Pharmaceutical Co., Ltd
Established in September 2004, Jiangxi Tianxin Pharmaceutical Co., Ltd is a high-tech enterprise specializing in the production of vitamins. Our main products include vitamin B6, vitamin B1, folic acid, biotin, and vitamin D3, which are mainly used in the fields of API, food additives, and feed additives. After more than a decade of development, the company has now formed a strategic development pattern integrating the Jiangxi production base, Shanghai R&D center, and Shanghai sales center. At present, they have the largest production and market share of vitamin b6.
3.2 DSM
DSM is a famous vitamin production giant. Their vitamin b6 production plant is in China.
3.3 Xinfa Pharmaceutical Co., Ltd
Xinfa Pharmaceutical Co., Ltd, founded in 1998, is a high-tech private enterprise mainly producing feed additives, vitamins, raw materials for veterinary drugs, and pharmaceutical intermediates. It is located in Dongying City, Shandong Province, in the hinterland of the Yellow River Delta on the coast of the Bohai Sea.
3.4 Huazhong Pharmaceutical Co., Ltd
Huazhong Pharmaceutical Co., Ltd, located in Xiangyang City, Hubei Province, is a modern comprehensive pharmaceutical enterprise integrating R&D, production, and sales of pharmaceutical products.
3.5 Hubei Guangji Pharmaceutical Co., Ltd (Huisheng)
Hubei Huisheng Pharmaceutical Co., Ltd is jointly invested by Hubei Guangji Pharmaceutical Co., Ltd., Xianning Jinghui Pharmaceutical Co., Ltd., and Hubei Harmony Pharmaceutical Co., Ltd. The design capacity of the new project is to produce 1000 tons of VB6 modern production line annually.
3.6 Shanghai Hegno Pharmaceutical Holding Co., Ltd
Shanghai Hegno Pharmaceutical Holding Co., Ltd is a high-tech company fully dedicated to the research, development, production, and marketing of high-quality pharmaceutical and nutritional ingredients. Headquartered in Shanghai, China, Hegno’s main production bases are located in Inner Mongolia and the Yangtze River Delta, with more than 60 years of experience in API manufacturing. Its vitamin products include biotin, riboflavin, and vitamin b6.
3.7 Zhejiang NHU Co., Ltd
Zhejiang NHU Co., Ltd was founded in 1999 and listed in 2004 (stock code 002001). It is one of the world’s leading vitamin manufacturers, with products covering vitamin a, vitamin e, vitamin D3, biotin, and coenzyme q10. In 2021, They began pilot production of vitamin b6 with a design capacity of 6,000 tons per year. In 2022, vitamin b6 is already on the market.
4. Vitamin b6 production method
Currently, vitamin B6 is usually produced by chemical synthesis, which is divided into pyridone, oxazole, alkynyl ether, and microbial methods. The oxazole method is the mainstream method used in industry, and most of the current research is focused on the improvement of the oxazole synthesis process, which has the advantages of easy availability of raw materials, high yield, and relatively low production cost.
5. Summary
The main manufacturers of vitamin b6 are Jiangxi Tianxin Pharmaceutical Co., Ltd, DSM, Xinfa Pharmaceutical Co., Ltd, Huazhong Pharmaceutical Co., Ltd, Hubei Guangji Pharmaceutical Co., Ltd (Hubei Huisheng Pharmaceutical Co., Ltd), Shanghai Hegno Pharmaceutical Holding Co., Ltd and Zhejiang NHU Co., Ltd.
Among them, Tianxin Pharmaceutical has the largest production and market share, and NHU is a new entrant.
