Caffeine anhydrous, CAS 58-08-2, chemical formula C8H10N4O2, molecular weight 194.19
It is a xanthine alkaloid compound, a central nervous system stimulant that temporarily drives away drowsiness and restores energy, and is used clinically for coma resuscitation. Caffeinated coffee, tea, soft drinks, and energy drinks are very popular, so caffeine is also the most commonly used psychotropic drug in the world.
In North America, 90% of adults use caffeine on a daily basis. Many natural sources of caffeine also contain a variety of other xanthine alkaloids, including the cardiac stimulants theophylline and theobromine, as well as other substances such as tannins.
The major manufacturers of caffeine anhydrous in China are as follows.
CSPC Innovation Pharmaceutical Co., Ltd
CSPC Innovation Pharmaceutical Co., Ltd. is a wholly owned subsidiary of CSPC Group. Since its establishment, it has been providing quality products and creating greater value for customers. At present, they have developed into an important global production base of chemically synthesized caffeine and have become one of the leading enterprises in China’s functional food industry. Over the years, based on two series of products, caffeine food additives, and vitamin C tablets, it has been deeply involved in China’s functional food production industry, establishing a product structure with a full range of products that can meet the needs of different consumers, establishing significant brand advantages and giving profound connotations to the products.
Shandong Xinhua Pharmaceutical Co., Ltd
As a core subsidiary of the pharmaceutical sector of Hualu Holding Group, Shandong Xinhua Pharmaceutical Co., Ltd. was founded in 1943 in the anti-Japanese base area of Jiaodong and is the first chemical synthetic pharmaceutical enterprise in New China, an important global production and export base of antipyretic and analgesic drugs, and an important domestic manufacturer of the cardiovascular, anti-infective and central nervous system. It has four pillar industries of chemical raw materials, pharmaceutical preparations, pharmaceutical intermediates, pharmaceutical commercial logistics, six industrial parks, and 14 subsidiaries. The scale of leading APIs such as ibuprofen, aspirin, and levodopa are among the top in the world.
Hebei Guangxiang Pharmaceutical Co., Ltd
Hebei Guangxiang Pharmaceutical Co., Ltd. was established in February 2017, located in Cangzhou City, Hebei Province, which is a subsidiary of Shijiazhuang Four Pharmaceuticals Group. The main products include azithromycin, aminophylline, metronidazole, and caffeine, with caffeine capacity reaching 12,000 tons per year.
Jilin Shulan Synthetic Pharmaceutical Co., Ltd
Jilin Shulan Synthetic Pharmaceutical Co., Ltd, approved by the state, has had the right to import and export since 1994, and after 1997, it not only holds a large market share in the domestic market, but also has international sales in Africa, Europe, Southeast Asia, and America. The company’s main product, caffeine, has the largest use in the food additive industry for cola-type drinks and functional drinks; the second use is for antipyretic and analgesic drugs, such as cold and flu medicines, and analgesics.
Reference：
http://www.e-cspc.com/about/group_4036.html
https://baike.baidu.com/item/%E5%92%96%E5%95%A1%E5%9B%A0/224340?fr=aladdin
