α-arbutin, also known as alpha-arbutin, CAS 84380-01-8.
β-arbutin, also known as beta-arbutin, CAS 497-76-7.
Arbutin, with the chemical formula C12H16O7, is a kind of ingredient extracted from the leaves of Arbutin, a plant of the Rhododendron family, which can reduce skin pigmentation and get rid of pigmentation and freckles by inhibiting the activity of tyrosinase in the body and stopping the production of melanin, as well as having bactericidal and anti-inflammatory effects, mainly used in cosmetics.
Arbutin can be divided into α and β types according to different structures, both of which have the effect of inhibiting tyrosinase enzyme to achieve whitening, and the most applied is β type, which has been studied in detail; and it is said that α type added to β type can inhibit the production of tyrosinase at a concentration of 1 in 9 to achieve the whitening effect, but detailed toxicological studies have not been seen. Many care products with alpha arbutin claim to have a ten times higher whitening effect than traditional arbutin, but the actual efficacy has not been confirmed by clear data and experimental reports, but the whitening effect is still certain. The biggest difference between the two in terms of physical properties is the degree of spin: α-arbutin is about 180 degrees, while β-arbutin is about -60 degrees.
Anhui Huaheng Biotechnology Co., Ltd
Anhui Huaheng Biotechnology Co., Ltd. is a high-tech enterprise with synthetic biotechnology at its core, mainly engaged in the research and development, production, and sales of amino acids and their derivative products. Its main products include alanine series products (L-alanine, DL-alanine, β-alanine), calcium D-pantothenate and α-arbutin, which can be widely used in many fields such as daily chemicals, pharmaceutical, and health products, food additives, and feed.
Hubei Artec Biotechnology Co., Ltd
Hubei Artec Biotechnology Co., Ltd. is located in Leihe Development Zone, Yicheng City, Hubei Province, China. The company mainly produces cosmetic additives and glycochemical products and is a major manufacturer of cosmetic whitening additives in the world. The company has a number of patented technologies, such as the synthesis technologies of arbutin, α-arbutin and ascorbic acid glucoside, etc. The scale product lines that have been put into production include arbutin, dipalmitate of triglyceride, α-arbutin, and ascorbic acid derivative series products.
Cheng Zhi Life Science co., Ltd
Cheng Zhi Life Science co., Ltd. is dedicated to the development of biological high-tech products, incubation of high-tech enterprises, and market development of products. Since its establishment, the company has completed the industrialization and development of a series of functional fermented products such as D-ribose, L-glutamine, L-theanine, L-arginine, and a-arbutin, forming the company’s core intellectual property rights, possessing dozens of domestic and foreign invention patents and forming a strong brand and quality advantage in the international market.
Beijing Brilliance Biotech Co., Ltd
Beijing Brilliance Biotech Co., Ltd. is a high-tech enterprise specializing in the production of functional cosmetic raw materials and pharmaceutical preparations. The company’s main products include functional cosmetic raw materials and pharmaceutical preparations such as anti-aging, whitening, acne treatment, and fermentation.
The company’s dozens of products such as vitamin A alcohol, arbutin, raspberry glucoside, palmitate of triglyceride, transaminic acid, vitamin C ethyl ether, octanoyl salicylic acid, etc. have been sold all over the world in large quantities, with advantageous production capacity and quality in the world and stable supply all year round.
Shandong Topscience Biotech Co., Ltd
Shandong Topscience Biotech Co., Ltd. is a pharmaceutical-grade sodium hyaluronate raw material research and development, production, sales, and service as one of technology-based company. Founded in 2005 and located in Rizhao City, Shandong Province, Zhongshan Biotechnology has a number of sodium hyaluronate industry chains, including pharmaceutical raw materials, cosmetic raw materials, and food raw materials. Its cosmetic raw materials also include α-arbutin and ascorbyl glucoside.
Anhui Tianyin Biotech Co., Ltd
Anhui Tianyin Biotech Co., Ltd. was established in 2011, located in Guzhen Economic Development Zone, Bengbu City, Anhui Province, China, covering an area of 15,000 square meters, a national high-tech enterprise. The company is dedicated to the R&D, production, and sales of vitamin C derivatives for cosmetic whitening additives, food additives, and feed additives, and has obtained EFFCI GMP, ISO, and REACH certifications.
Main products: Vitamin C sodium phosphate, Vitamin C magnesium phosphate, L-ascorbic acid 2-glucoside, α-arbutin, liquid multivitamin, with an annual production capacity of 1000 tons.
HYUNDAI BIOLAND
HYUNDAI BIOLAND enhances beauty by providing the best quality raw materials for cosmetics that are nontoxic and non-irritant by natural extraction, microbial fermentation, and organic synthesis.
DSM
Many consumers still struggle to find the right product to achieve a natural even skin tone. But, thanks to its high efficacy, ALPHA-ARBUTIN has gained wide acceptance and is rated highly by people from all walks of life. Cosmetic products with the skincare ingredient ALPHA-ARBUTIN typically inhibit tyrosinase, one of the major enzymes involved in the formation of skin tan and age spots. ALPHA-ARBUTIN reduces the degree of skin tanning after UV exposure and helps to minimize the appearance of liver spots.
GfN Selco
Alpha-Arbutin is Very effective skin whitener with pronounced antioxidant properties.
Alpha-Arbutin controls the build-up of senile keratosis, freckles, pigmented lesions, and age spots, and also minimizes liver spots. It’s the ideal active ingredient for skin lightening and anti-aging cosmetics like creams, lotions, essences, face masks, and foundations.
Mitsubishi Chemical Corporation
β-Arbutin is used as a whitening ingredient for controlling the generation of melanin pigments, which are substances causing discoloration and freckles.
It is known as a substance contained in ericaceous herbs called bearberry leaf. Discoloration and freckles occur due to reactive oxygen produced in the skin by exposure to UV in sunlight, stress, atmospheric pollution, etc., which activates tyrosinase, and the activated enzyme promotes the conversion of tyrosine in melanocytes (pigment cells) to melanin pigments.
References:
https://baike.baidu.com/item/%E7%86%8A%E6%9E%9C%E8%8B%B7/2457270?fr=aladdin
https://baike.baidu.com/item/%CE%B1-%E7%86%8A%E6%9E%9C%E8%8B%B7/1380841
