1. Sodium hyaluronate
Generally speaking, hyaluronic acid is also known as sodium hyaluronate.
Sodium hyaluronate, CAS No. 9067-32-7, EINECS No. 232-678-0, chemical formula (C14H20NO11Na)n.
Sodium hyaluronate is an intrinsic component of the human body, a dextran aldehyde acid with no species specificity, which is widely present in tissues and organs such as the placenta, amniotic fluid, lens, articular cartilage, and skin dermis. It is distributed in the cytoplasm and intercellular matrix and acts as a lubricant and nourisher for the cells contained therein and the cellular organ itself.
The sodium hyaluronate mentioned in this article is derived from the fermentation of Streptococcus equi.
2. The role of sodium hyaluronate
1. It is used in eye drops and in the treatment of arthritis to improve the efficacy of the drug and to assist in the therapeutic effect.
2. It is added to cosmetics to have anti-wrinkle, moisturizing, and anti-aging effects.
3. Sodium hyaluronate is used to repair and prevent light burns or sunburns caused by sun exposure to the skin.
4. In food, HA also has the role of nutrition and moisturizing, thickening
3. Classification of sodium hyaluronate
1. According to the application area, sodium hyaluronate is classified into food grade, cosmetic grade, and pharmaceutical grade (injection grade and eye drop grade)
2. According to the classification of molecular weight, it is divided into oligo sodium hyaluronate ≤0.1MDa, low molecular 0.1-0.8MDa, medium molecular 0.8-1.5MDa, high molecular sodium hyaluronate ≥1.5MDa.
3. Also, there are some special functional products, 4D-sodium hyaluronate.
4. Manufacturers of Sodium Hyaluronate
The main manufacturers of sodium hyaluronate are Bloomage Biotechnology Corporation Limited., Shandong Focuschem Biotech Co., Ltd., Shandong AWA Biopharm Co. Ltd, Fufeng Group, Shandong Topscience Biotech Co., Ltd, Dongying First Biochem Industrial Co., Ltd, Contipro and Kewpie.
4.1 Bloomage Biotechnology Corporation Limited
Bloomage Biotechnology Corporation Limited is a well-known biotechnology company and bioactive materials company, mainly focusing on functional glycans and amino acids that contribute to human health, dedicated to bringing a new experience of healthy, beautiful, and happy life to human beings.
We have developed a series of bioactive products with hyaluronic acid as the core. Among them, hyaluronic acid includes pharmaceutical grade, cosmetic grade, and food grade. Other bioactive products include ectoin, ergothioneine, γ-aminobutyric acid, polyglutamic acid, micronucleus gum hydrogel, natto extract, brown rice fermentation filtrate, etc.
Their sodium hyaluronate has the largest market share.
4.2 Shandong Focuschem Biotech Co., Ltd
Shandong Focuschem Biotech Co., Ltd. was founded in 2007 and is located in Qufu City, Shandong Province, and acquired by Lushang Property Co., Ltd. in 2020, They are a national high-tech enterprise integrating R&D, production, and sales of sodium hyaluronate.
4.3 Shandong AWA Biopharm Co. Ltd
Shandong AWA Biopharm Co. Ltd was established in 2010, located in Binzhou City, Shandong Province is a high-tech enterprise integrating the production, R&D, and sales of hyaluronic acid, and has become an international manufacturer and supplier of hyaluronic acid raw materials with the mature production process, stable product quality, and professional sales team.
4.4 Fufeng Group
Fufeng Group is an international bio-fermentation products company listed on the Main Board of the Hong Kong Stock Exchange. It focuses on the research, development, production, and operation of various amino acids and their derivatives and bio colloids, and is a world-renowned manufacturer of MSG, xanthan gum, amino acids, and sodium hyaluronate.
4.5 Shandong Topscience Biotech Co., Ltd
Shandong Topscience Biotech Co., Ltd was established in 2005, located in Rizhao City, Shandong Province, and has a number of sodium hyaluronate industry chains, including pharmaceutical raw materials, cosmetic raw materials, and food raw materials. It is a technology-based company integrating R&D, production, sales, and service. Topscience is committed to becoming a benchmark enterprise of sodium hyaluronate in China and even in the world for the benefit of human health.
4.6 Dongying First Biochem Industrial Co., Ltd
Dongying First Biochem Industrial Co., Ltd was founded in 2001, the company takes biotechnology as the leading industry and is a high-tech enterprise of the Ministry of Science and Technology. The company is dedicated to the research and production of cosmetic-grade and food-grade hyaluronic acid and other biochemical raw materials. It was acquired by Bloomage Biotechnology Corporation Limited in 2020, further consolidating its position as the No.1 in the industry.
4.7 Contipro
Contipro is a Czech-based company with tradition since 1990. Our flagship product is biotechnologically manufactured hyaluronic acid of the highest quality and purity. Contipro stands on mutually supporting pillars of active substances, pharmaceutical products, and innovative devices.
4.8 Kewpie
Kewpie Group started sales of hyaluronic acid (derived from the chicken comb) for cosmetic applications in 1983. In 2004, they started sales of hyaluronic acid (microbially fermented).
5. Summary
The main manufacturers of hyaluronic acid are Bloomage Biotechnology Corporation Limited., Shandong Focuschem Biotech Co., Ltd., Shandong AWA Biopharm Co. Ltd, Fufeng Group, Shandong Topscience Biotech Co., Ltd, Dongying First Biochem Industrial Co., Ltd, Contipro and Kewpie.
In China, Shandong Province is the production cluster of hyaluronic acid.
Bloomage Biotechnology Corporation Limited has the biggest market share for sodium hyaluronate.
